Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

927473

Sigma-Aldrich

CA-alkyne

≥95%

Synonym(s):

2-Chloro-N-(hex-5-yn-1-yl)acetamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H12ClNO
CAS Number:
1046120-17-5
Molecular Weight:
173.64
MDL number:
MFCD34475508
UNSPSC Code:
12352101
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

semisolid

storage temp.

−20°C

SMILES string

ClCC(=O)NCCCCC#C

InChI

1S/C8H12ClNO/c1-2-3-4-5-6-10-8(11)7-9/h1H,3-7H2,(H,10,11)

InChI key

YQDXXLTYDIDZDT-UHFFFAOYSA-N

Application

CA-alkyne is a probe that can be used for labeling cysteines through alkylation. For the corresponding negative control, see CA-nitrile. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications. The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis. Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

927473-50MG:
927473-BULK:
927473-VAR:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Profiling the proteome-wide selectivity of diverse electrophiles
Zanon, et al
ChemRxiv : the preprint server for chemistry (2021)
Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)
Eranthie Weerapana et al.
Nature, 468(7325), 790-795 (2010-11-19)
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here we

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service