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Safety Information

925047

Sigma-Aldrich

KB02-COOH

Synonym(s):

2-((1-(2-Chloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl)oxy)acetic acid, Functionalized scout fragment

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About This Item

Empirical Formula (Hill Notation):
C13H14ClNO4
CAS Number:
2375196-30-6
Molecular Weight:
283.71
MDL number:
MFCD00003568
NACRES:
NA.22

reaction suitability

reagent type: chemical modification reagent

Quality Level

100

storage temp.

2-8°C

Application

KB02-COOH is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include cysteine fragment KB02 (912131), KB02-SLF (914738), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Technology spotlight: Proteomic Ligandability Assessment

Other Notes

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

925047-VAR:
925047-BULK:
925047-10MG:

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