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924520

Sigma-Aldrich

4-Methoxybenzyl chloride

Synonym(s):

4-(Chloromethyl)anisole

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About This Item

Linear Formula:
CH3OC6H4CH2Cl
CAS Number:
824-94-2
Molecular Weight:
156.61
Beilstein:
606667
MDL number:
MFCD00000915
UNSPSC Code:
41116105
NACRES:
NA.22

form

liquid

Quality Level

100

refractive index

n20/D 1.548 (lit.)

bp

117-118 °C/14 mmHg (lit.)

mp

−1 °C (lit.)

density

1.155 g/mL at 25 °C (lit.)

functional group

chloro

storage temp.

2-8°C

SMILES string

COc1ccc(CCl)cc1

InChI

1S/C8H9ClO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3

InChI key

MOHYOXXOKFQHDC-UHFFFAOYSA-N

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Application

4-Methoxybenzyl chloride can be used as a reactant:
  • To synthesize 4-methoxybenzyl esters by reacting with cyclic anhydrides.
  • In the mono-alkylation of trans-1,2-diaminocyclohexane.
It can also be used as a:
  • Protecting group for amino acids during peptide synthesis using triethylamine as a base.
  • Co-catalyst in the intramolecular carboamination of aminodienes to N-heterocyclesvia benzyl-group transfer.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

228.2 °F - closed cup

Flash Point(C)

109 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

924520-BULK:
924520-VAR:
924520-25G:

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