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Safety Information

910015

Sigma-Aldrich

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

Synonym(s):

Azido-PEG5-CH2CO2H, Azido-PEG5-acid, N3-PEG5-CH2COOH

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About This Item

Empirical Formula (Hill Notation):
C12H23N3O7
CAS Number:
217180-81-9
Molecular Weight:
321.33
MDL number:
MFCD31561141
UNSPSC Code:
12352106

Assay

≥95%

form

(Liquid or Semi-solid or Paste or Solid)

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

functional group

azide
carboxylic acid

storage temp.

2-8°C

SMILES string

OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Application

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG5-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

910015-BULK:
910015-100MG:
910015-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCL1557

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