Skip to Content
Merck
All Photos(3)

Key Documents

Safety Information

909432

Sigma-Aldrich

Fluorinated VHL Spy Molecule 2

≥98%

Synonym(s):

(2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C14H14BrF3N2O3
CAS Number:
Molecular Weight:
395.17
UNSPSC Code:
12352101

ligand

VH032 derivative

Assay

≥98%

form

powder

SMILES string

O=C([C@@H]1C[C@@H](O)CN1C(C(F)(F)F)=O)NCC2=CC=C(Br)C=C2

Application

Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

909432-100MG:
909432-BULK:
909432-VAR:
909432-10MG:


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service