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Safety Information

900664

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)(50:50)-b-poly(ethylene glycol)

10k-2k

Synonym(s):

PLGA-b-PEG, PLGA-PEG

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About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

form

chunks

storage temp.

2-8°C

Related Categories

Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(D,L-lactide-co-glycolide) (PLGA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

900664-500MG:
900664-VAR:
900664-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCF1600
MKCG0738

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Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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