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656682

Sigma-Aldrich

Chloromethyl chlorosulfate

97%

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About This Item

Linear Formula:
ClCH2OSO2Cl
CAS Number:
49715-04-0
Molecular Weight:
165.00
EC Number:
256-442-1
MDL number:
MFCD00041547
UNSPSC Code:
12352100
PubChem Substance ID:
24884216
NACRES:
NA.22

Quality Level

100

Assay

97%

refractive index

n20/D 1.448

bp

45-50 °C/10 mmHg

density

1.631 g/mL at 25 °C

functional group

chloro

storage temp.

2-8°C

SMILES string

ClCOS(Cl)(=O)=O

InChI

1S/CH2Cl2O3S/c2-1-6-7(3,4)5/h1H2

InChI key

PJBIHXWYDMFGCV-UHFFFAOYSA-N

Application

Reagent for chloromethylation of Fmoc-protected amino acids without the generation of carcinogenic bis(chloromethyl)ether.

Signal Word

Danger

Hazard Statements

H302,H314,H330,H350

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 4 Oral - Carc. 1A - Skin Corr. 1B

Storage Class Code

5.1B - Oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

656682-2G:
656682-BULK:
656682-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ5288
MKCK7152
MKCC5620
MKBX2332V

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Nicholas P Power et al.
Organic & biomolecular chemistry, 2(10), 1554-1562 (2004-05-12)
The reaction of liquid (gamma-) SO3 with CH2Cl2 at room temperature leads to SO3 insertion into the C-Cl bonds, giving the useful chloromethylating agent chloromethyl chlorosulfate (CMCS). The process is very slow but becomes rapid on addition of catalytic quantities

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