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646598

Sigma-Aldrich

Cyclobutylboronic acid

≥95.0%

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About This Item

Empirical Formula (Hill Notation):
C4H9BO2
CAS Number:
849052-26-2
Molecular Weight:
99.92
MDL number:
MFCD06798108
UNSPSC Code:
12352103
PubChem Substance ID:
24883473
NACRES:
NA.22

Assay

≥95.0%

form

solid

mp

118-123 °C (lit.)

storage temp.

2-8°C

SMILES string

OB(O)C1CCC1

InChI

1S/C4H9BO2/c6-5(7)4-2-1-3-4/h4,6-7H,1-3H2

InChI key

MIUALDDWOKMYDA-UHFFFAOYSA-N

Related Categories

Application

  • Reagent used in palladium-catalyzed arylation and alkylation of diphenylisoxazole with boronic acids via C-H activated isoxazole palladacycle intermediate

  • Reagent used in the preparation of cyclobutyl arenes and heteroarenes via palladium catalyzed Suzuki-Miyaura cross-coupling reaction of potassium cyclobutyltrifluoroborate intermediate with aryl and heteroaryl chlorides

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

JAN Code

646598-500MG:
646598-VAR:
646598-BULK:
646598-2G:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBL3412
SHBG1656V
SHBD6995V
SHBD1651V
SHBC6054V

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Palladium-Catalyzed Arylation and Alkylation of 3,5-Diphenylisoxazole with Boronic Acids via C-H Activation
J. Chu, et al.,
Organometallics, 27, 5173-5176 (2008)
Gary A Molander et al.
The Journal of organic chemistry, 73(19), 7481-7485 (2008-09-02)
Suitable conditions were found for the Suzuki-Miyaura cross-coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates with aryl chlorides. Both of these secondary alkyl trifluoroborates coupled in moderate to excellent yield with electron-rich, electron-poor, and hindered aryl chlorides to give a variety

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