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641472

Sigma-Aldrich

1-Boc-4-(aminomethyl)piperidine

97%

Synonym(s):

1,1-Dimethylethyl 4-(aminomethyl)-1-piperidinecarboxylate, N-(tert-Butoxycarbonyl)-4-aminomethylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C11H22N2O2
CAS Number:
Molecular Weight:
214.30
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

refractive index

n20/D 1.473 (lit.)

bp

237-238 °C (lit.)

density

1.013 g/mL at 25 °C (lit.)

SMILES string

CC(C)(C)OC(=O)N1CCC(CN)CC1

InChI

1S/C11H22N2O2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-8,12H2,1-3H3

InChI key

KLKBCNDBOVRQIJ-UHFFFAOYSA-N

Application

Precursor in the preparation of a variety of different protein agonists or antagonists including:
  • Kinesin spindle protein inhibitors with potential anticancer activity
  • Orphan G-protein coupled receptor GPR119 agonist with antidiabetic potential
  • Pim-1 inhibitors
  • Aspartic acid protease inhibitors

Reactant involved in enantioselective synthesis of N-alkyl terminal aziridines

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

641472-VAR:
641472-25G:
641472-5G:
641472-BULK:


Certificates of Analysis (COA)

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Articles

Mono-Boc-protected diamines are versatile building blocks for chemical synthesis. Their production is a lot more challenging than the simple reaction scheme might imply, because the Boc-anhydride reagent cannot differentiate between the two identical amino moieties in the substrate.

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