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568562

Sigma-Aldrich

Poly(L-lactide-co-caprolactone-co-glycolide)

L-lactide 70 %, average Mn ~50,000 by GPC

Synonym(s):

ε-Caprolactone-glycolide-L -lactide copolymer, Poly-L -lactide-co-glycolide-co-ε-caprolactone

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About This Item

CAS Number:
134490-19-0
MDL number:
MFCD04041034
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

feed ratio

lactide:caprolactone:glycolide 70:20:10

mol wt

average Mn ~50,000 by GPC

composition

L-lactide, 70%

transition temp

Tg ~28 °C

storage temp.

2-8°C

Related Categories

Application

Poly(L-lactide-co-caprolactone-co-glycolide) (PLGA-PCL) is a biodegradable block copolymer that may be used as nanoparticle-based drug delivery systems. Electrospun nanofiber blend of PLGA-PCL, phosphorylcholine groups and an antiproliferative (rapamycin)may be used as vascular grafts and prostheses.

Features and Benefits

Biocompatible, biodegradable polymer.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

568562-5G:
568562-BULK:
568562-1G:
568562-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCG1972
MKCG1973
MKCD3489
MKBW5729V
MKBT8119V

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Preparation of electrospun poly (L-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application.
Kim H I, et al.
Current Applied Physics, 9(4), e249-e251 (2009)
Novel docetaxel-loaded nanoparticles based on poly (lactide-co-caprolactone) and poly (lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies.
Sanna V, et al.
Nanoscale Research Letters, 6(1), 260-260 (2011)

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