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56210

Sigma-Aldrich

3-Hydroxypiperidine

≥98.0% (NT)

Synonym(s):

3-Piperidinol

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About This Item

Empirical Formula (Hill Notation):
C5H11NO
CAS Number:
6859-99-0
Molecular Weight:
101.15
Beilstein:
102696
EC Number:
229-957-4
MDL number:
MFCD00014591
UNSPSC Code:
12352100
PubChem Substance ID:
57651571
NACRES:
NA.22

Assay

≥98.0% (NT)

form

solid

mp

57-61 °C

solubility

H2O: 1 g/mL, clear

functional group

hydroxyl

storage temp.

2-8°C

SMILES string

OC1CCCNC1

InChI

1S/C5H11NO/c7-5-2-1-3-6-4-5/h5-7H,1-4H2

InChI key

BIWOSRSKDCZIFM-UHFFFAOYSA-N

General description

3-Hydroxypiperidine can be obtained from the reduction of 3-hydroxypyridine.

Application

3-Hydroxypiperidine may be used to synthesize the following:
  • 2-pyrrolidinone via oxidation with iodosylbenzene
  • 1-[2,8-bis(trifluoromethyl)quinolin-4-yl]piperidin-3-ol via reaction with 4-bromoquinoline
Reactant for:
Synthesis of unsymmetrical ureas
Synthesis of piperidine nucleoside analogs
Fluorination reactions
Synthesis of substituted pyridines

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H315,H318

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

56210-BULK:
56210-VAR:
56210-50G:
56210-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCBS4837V
1391403V
1351670V
1438752
1391403

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Katritzky.RA, et al.
Comprehensive Organic Functional Group Transformations II, 1 (1995)
Synthesis of quinoline analogs: search for antimalarial agents
Babu R K, et al.
Monatshefte fur Chemie / Chemical Monthly, 139(2), 179-181 (2008)
Oxidation of 3-hydroxypiperidines with iodosylbenzene in water: Tandem oxidative Grob fragmentation-cyclization reaction
Tada N, et al.
Chemical & Pharmaceutical Bulletin, 52(9), 1143-1144 (2004)

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