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Safety Information

549975

Sigma-Aldrich

3-(Diethylamino)propylamine

≥99%

Synonym(s):

N,N-Diethyl-1,3-diaminopropane, N,N-Diethyl-1,3-propanediamine, DEAPA

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About This Item

Linear Formula:
(C2H5)2N(CH2)3NH2
CAS Number:
104-78-9
Molecular Weight:
130.23
Beilstein:
741879
EC Number:
203-236-4
MDL number:
MFCD00008218
UNSPSC Code:
12352100
PubChem Substance ID:
24874737
NACRES:
NA.22

vapor density

4.4 (vs air)

Quality Level

200

vapor pressure

19.5 mmHg ( 70 °C)

Assay

≥99%

autoignition temp.

419 °F

expl. lim.

11.6 %

refractive index

n20/D 1.4416 (lit.)

bp

159 °C (lit.)

density

0.826 g/mL at 25 °C (lit.)

functional group

amine

SMILES string

CCN(CC)CCCN

InChI

1S/C7H18N2/c1-3-9(4-2)7-5-6-8/h3-8H2,1-2H3

InChI key

QOHMWDJIBGVPIF-UHFFFAOYSA-N

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General description

3-(Diethylamino)propylamine (3-(diethylamino)-1-propylamine, DEAPA) is a diamine.

Application

3-(Diethylamino)propylamine may be used in the preparation of:
  • Biocompatible polyampholyte-coated (poly(acrylic acid)-co-3-(diethylamino)-propylamine magnetite nanoparticles (PAMNPs).
  • Hyaluronic acid grafted with 3-diethylaminopropyl (DEAP) group (HA-g-DEAP) nanoparticles for use as a drug delivery vehicle.
  • DEAPA-modified poly(vinyl alcohol) (PVA) polymers that can be employed in gene silencing.
It may also be used to introduce cationic groups during the surface modification of microfibrillated cellulose (MFC).

Legal Information

Product of Arkema Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

549975-100ML:
549975-VAR:
549975-2L:
549975-500ML:
549975-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ1088
MKCN8431
MKCK4279
MKCH9535
MKCG0291

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Low toxicity and long circulation time of polyampholyte-coated magnetic nanoparticles for blood pool contrast agents.
Wang Qi, et al.
Scientific Reports, 5, 7774-7774 (2015)
Juliane Nguyen et al.
Pharmaceutical research, 27(12), 2670-2682 (2010-09-18)
The objective of this study was to investigate how the degree of amine substitution of amine-modified poly(vinyl alcohol) (PVA) affects complexation of siRNA, protection of siRNA against degrading enzymes, intracellular uptake and gene silencing. A series of DEAPA-PVA polymers with
Chemical surface modifications of microfibrillated cellulose.
Stenstad P, et al.
Cellulose, 15(1), 35-45 (2008)
Hyaluronated nanoparticles with pH-and enzyme-responsive drug release properties.
Kim SW, et al.
Colloids and Surfaces. B, Biointerfaces, 116, 359-364 (2014)

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