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Safety Information

535087

Sigma-Aldrich

2-Fluoroadenine

96%

Synonym(s):

2-Fluoro-7(9)H-purin-6-ylamine

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About This Item

Empirical Formula (Hill Notation):
C5H4FN5
CAS Number:
700-49-2
Molecular Weight:
153.12
MDL number:
MFCD01632749
UNSPSC Code:
12352100
PubChem Substance ID:
24878071
NACRES:
NA.22

Quality Level

100

Assay

96%

mp

>350 °C (lit.)

functional group

fluoro

SMILES string

Nc1[nH]c(F)nc2ncnc12

InChI

1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)

InChI key

WKMPTBDYDNUJLF-UHFFFAOYSA-N

Related Categories

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

535087-1G:
535087-BULK:
535087-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8503
MKCM9485
MKBX3163V
MKBS0630V
MKBP5093V

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Lincoln G Scott et al.
Journal of the American Chemical Society, 126(38), 11776-11777 (2004-09-24)
The production of isotopically labeled RNA remains critical to current NMR structural studies. One approach to obtain simple NMR spectra is to label with a nucleus that is not naturally occurring in RNA. Fluorine-19 can serve as a sensitive site-specific
Yukio Kitade et al.
Nucleic acids research. Supplement (2001), (3)(3), 5-6 (2003-09-27)
Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.
P Huang et al.
Biochemical pharmacology, 36(18), 2945-2950 (1987-09-15)
2-Fluoroadenine (F-Ade) is a metabolite of 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) that may be involved in the development of toxic side effects from this anticancer drug. The liberation of F-Ade from F-ara-A has been examined in different biological systems. Extracts of Escherichia coli
D Voeks et al.
Gene therapy, 9(12), 759-768 (2002-06-01)
A gene-directed enzyme pro-drug therapy (GDEPT) based on purine nucleoside phosphorylase (PNP), that converts the prodrug, fludarabine to 2-fluoroadenine, has been described, but studies are limited compared with other GDEPTs. We investigated the in vitro and in vivo efficacies of
Song Ye et al.
Nucleosides, nucleotides & nucleic acids, 22(10), 1899-1905 (2003-11-12)
A convenient synthesis of 2'-deoxy-2-fluoroadenosine from commercially available 2-fluoroadenine is described. The coupling reaction of silylated 2-fluoroadenine with phenyl 3,5-bis[O-(t-butyldimethylsilyl)]-2-deoxy-1-thio-D-erythro-pentofuranoside gave the corresponding 2-fluoro-2'-deoxyadenosine derivative (alpha/beta = 1:1) in good yield. The alpha- and beta-anomers were separated by chromatography, and
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