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528943

Sigma-Aldrich

4-Fluoro-2-methoxyphenol

97%

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About This Item

Linear Formula:
FC6H3(OCH3)OH
CAS Number:
450-93-1
Molecular Weight:
142.13
MDL number:
MFCD00070797
UNSPSC Code:
12352100
PubChem Substance ID:
24877629
NACRES:
NA.22

Quality Level

100

Assay

97%

refractive index

n20/D 1.517 (lit.)

bp

195 °C (lit.)

density

1.247 g/mL at 25 °C (lit.)

functional group

fluoro

SMILES string

COc1cc(F)ccc1O

InChI

1S/C7H7FO2/c1-10-7-4-5(8)2-3-6(7)9/h2-4,9H,1H3

InChI key

OULGLTLTWBZBLO-UHFFFAOYSA-N

Related Categories

General description

4-Fluoro-2-methoxyphenol is a fluorinated methoxy-substituted catechol analog.

Application

4-Fluoro-2-methoxyphenol may be used in the synthesis of:
  • 4-halo-masked o-benzoquinones (MOBs)
  • fluorinated masked o-benzoquinone
  • poly(4-fluoro-2-methoxyphenol)

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

214.9 °F - closed cup

Flash Point(C)

101.6 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

528943-BULK:
528943-1G:
528943-5G:
528943-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH1396
MKCF6363
05125AE
07026LD
09817KD

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Diels-Alder reactions of halogenated masked o-benzoquinones: synthesis of halogen-substituted bicyclo [2.2. 2] octenones.
Tetrahedron Letters, 50(7), 773-775 (2009)
Ana Carolina de Almeida et al.
European journal of pharmacology, 660(2-3), 445-453 (2011-04-19)
Apocynin, a methoxy-substituted catechol (4-hydroxy-3-methoxyacetophenone), originally extracted from the roots of Picrorhiza kurroa, has been extensively used as a non-toxic inhibitor of the multienzymatic complex NADPH oxidase. We discovered that the analogous methoxy-substituted catechol, 4-Fluoro-2-methoxyphenol (F-apocynin), in which the acetyl
Novel photoconductive polyfluorophenol synthesized by an enzyme.
Zaragoza-Gasca P, et al.
Journal of Molecular Catalysis. B, Enzymatic, 72(1), 25-27 (2011)
A fluorinated masked o-benzoquinone.
Patrick TB, et al.
Journal of Fluorine Chemistry, 125(12), 1965-1966 (2007)
P K Chakraborty et al.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 42(7), 673-681 (1991-01-01)
The synthesis of 4-[18F]fluoroguaiacol (4-[18F]fluoro-2-methoxyphenol) has been achieved in no-carrier-added form starting from 2-methoxy-4-nitrobenzaldehyde, using nucleophilic aromatic substitution by [18F]fluoride followed by Baeyer-Villiger oxidation of the benzaldehyde to the phenol. Demethylation with boron tribromide gave 4-[18F]fluorocatechol (1,2-dihydroxy-4-[18F]fluorobenzene) with an overall

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