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486825

Sigma-Aldrich

L-Leucine-5,5,5-d3

99 atom % D

Synonym(s):

SILAC Amino Acid

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About This Item

Linear Formula:
CH3CH(CD3)CH2CH(NH2)CO2H
CAS Number:
87828-86-2
Molecular Weight:
134.19
MDL number:
MFCD00144628
UNSPSC Code:
12352209
PubChem Substance ID:
24872215
NACRES:
NA.12

isotopic purity

99 atom % D

Quality Level

200

Assay

99% (CP)

form

solid

optical activity

[α]25/D +14.5°, c = 2 in 5 M HCl

technique(s)

protein expression: suitable

mp

>300 °C (lit.)

mass shift

M+3

SMILES string

[2H]C([2H])([2H])C(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1D3/t4?,5-

InChI key

ROHFNLRQFUQHCH-LONBSJBQSA-N

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General description

L-leucine-5,5,5-d3 is an isotopic analogue of L-leucine.

Application

L-leucine-5,5,5-d3 is used in the quantitative determination of proteins using mass spectrometry and also used in the synthesis of (2S,4R)-(5,5,5-d3)leucine via stereospecific manner.
Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

486825-BULK:
486825-1G-PW:
486825SP-BULK:
486825-VAR:
486825-1G:

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Certificates of Analysis (COA)

Lot/Batch Number
MBBD3233
MBBD1114
MBBC8522
MBBC3922
MBBC2381

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L-Isoleucine-13C6,15N 98 atom % 15N, 98 atom % 13C, 95% (CP)

Sigma-Aldrich

608092

L-Isoleucine-13C6,15N

Gerald W Becker
Briefings in functional genomics & proteomics, 7(5), 371-382 (2008-12-25)
Straightforward methods for the introduction of stable isotopes into proteins with subsequent isolation and purification of the proteins will greatly aid the field of quantitative proteomics. Proteins containing amino acids with one or more of the stable isotopes of deuterium

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