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466964

Sigma-Aldrich

4′-Fluoro-2′-hydroxyacetophenone

98%

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About This Item

Linear Formula:
FC6H3(OH)COCH3
CAS Number:
1481-27-2
Molecular Weight:
154.14
MDL number:
MFCD00143203
UNSPSC Code:
12352100
PubChem Substance ID:
24870373
NACRES:
NA.22

Assay

98%

mp

31-35 °C (lit.)

SMILES string

CC(=O)c1ccc(F)cc1O

InChI

1S/C8H7FO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3

InChI key

HLTBTUXAMVOKIH-UHFFFAOYSA-N

General description

4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P21/n.

Application

4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.
Used recently in the preparation of medicinally active benzo[b]furans and thiophenes.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

210.2 °F - closed cup

Flash Point(C)

99 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

466964-VAR:
466964-BULK:
466964-1G:
466964-5G:

Certificates of Analysis (COA)

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4'-Fluoro-2'-hydroxyacetophenone.
Rizal MR and Ng SW.
Acta Crystallographica Section E, Structure Reports Online, 64(5), o916-o916 (2008)
Khaled R A Abdellatif et al.
Journal of enzyme inhibition and medicinal chemistry, 30(3), 484-491 (2014-09-10)
In an effort to develop safe and potent anti-inflammatory agents, a series of novel 4'-fluoro-2'-hydroxychalcones 5a-d and their dihydropyrazole derivatives 6a-d was prepared. It was synthesized via aldol condensation of 4'-fluoro-2'-hydroxyacetophenone with appropriately substituted aldehydes followed by cyclization with hydrazine
M J Moonen et al.
Journal of industrial microbiology & biotechnology, 26(1-2), 35-42 (2001-09-11)
The biological Baeyer-Villiger oxidation of acetophenones was studied by 19F nuclear magnetic resonance (NMR). The 19F NMR method was used to characterise the time-dependent conversion of various fluorinated acetophenones in either whole cells of Pseudomonas fluorescens ACB or in incubations
Journal of Heterocyclic Chemistry, 30, 445-445 (1993)

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