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380059

Sigma-Aldrich

4-Chloro-3-nitrobenzonitrile

97%

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About This Item

Linear Formula:
ClC6H3(NO2)CN
CAS Number:
939-80-0
Molecular Weight:
182.56
Beilstein:
1639111
EC Number:
213-364-2
MDL number:
MFCD00016987
UNSPSC Code:
12352100
PubChem Substance ID:
24863715
NACRES:
NA.22

Assay

97%

form

powder

mp

98-100 °C (lit.)

functional group

chloro
nitrile
nitro

SMILES string

[O-][N+](=O)c1cc(ccc1Cl)C#N

InChI

1S/C7H3ClN2O2/c8-6-2-1-5(4-9)3-7(6)10(11)12/h1-3H

InChI key

XBLPHYSLHRGMNW-UHFFFAOYSA-N

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General description

FT-IR and μ-Raman spectra of 4-chloro-3-nitrobenzonitrile have been recorded in the range of 400-4000cm-1 and 100-4000cm-1, respectively. It has been prepred from the reaction of 4-chloro-3-nitrobenzamide and phosphorus oxychloride. Crystal structure of 4-chloro-3-nitrobenzonitrile has been reported. Molecules of 4-chloro-3-nitrobenzonitrile are linked by weak intermolecular C-H…O and C-H…N hydrogen bonds.

Application

4-Chloro-3-nitrobenzonitrile may be employed for the radiosynthesis of analogs of serotonin transporter (SERT) ligands for use in positron emission tomography (PET) studies and for the preparation of N-(4-cyano-2-nitrophenyl)glycine.
4-Chloro-3-nitrobenzonitrile may be used in the synthesis of 3-nitro-4-thiocyanobenzonitryl.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

380059-10KG:
380059-VAR:
380059-5G:4548173141923
380059-25G:4548173141916
380059-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
STBK6219
BCCF0175
STBJ7645
STBJ5834
BCCB9401

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Galina R Demina et al.
PloS one, 4(12), e8174-e8174 (2009-12-18)
Resuscitation promoting factors (RPF) are secreted proteins involved in reactivation of dormant actinobacteria, including Mycobacterium tuberculosis. They have been considered as prospective targets for the development of new anti-tuberculosis drugs preventing reactivation of dormant tubercle bacilli, generally associated with latent
Bo-Nian Liu et al.
Acta crystallographica. Section E, Structure reports online, 65(Pt 1), o92-o92 (2008-01-01)
In the title compound, C(7)H(3)ClN(2)O(2), the Cl, C and N atoms are coplanar with the aromatic ring. In the crystal structure, weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds link the mol-ecules. The π-π contact between the benzene rings, [centroid-centroid distances
Yusuf Sert et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 107, 248-255 (2013-02-26)
In the present study, the experimental and theoretical harmonic and anharmonic vibrational frequencies of 4-chloro-3-nitrobenzonitrile were investigated. The experimental FT-IR (400-4000 cm(-1)) and μ-Raman spectra (100-4000 cm(-1)) of the molecule in the solid phase were recorded. Theoretical vibrational frequencies and
S X Cai et al.
Journal of medicinal chemistry, 40(5), 730-738 (1997-02-28)
We report on a series of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones (QXs), prepared as a continuation of our structure-activity relationship (SAR) study of QXs as antagonists for the glycine site of the N-methyl-D-aspartate (NMDA) receptor. The in vitro potency of these
A A Wilson et al.
Journal of medicinal chemistry, 43(16), 3103-3110 (2000-08-24)
A series of four 2-(phenylthio)araalkylamines have been radiolabeled with (11)C and evaluated as potential radiotracers for imaging the serotonin transporter (SERT) by positron emission tomography (PET). All four candidates display high affinity for SERT and low affinity for the dopamine

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