Lorenzo Di Cesare Mannelli et al.
PloS one, 10(6), e0128080-e0128080 (2015-06-04)
Neurotoxicity is a main side effect of the anticancer drug oxaliplatin. The development of a neuropathic syndrome impairs quality of life and potentially results in chemotherapy dose reductions and/or early discontinuation. In the complex pattern of molecular and morphological alterations...
Rocio Gómez-Cansino et al.
Evidence-based complementary and alternative medicine : eCAM, 2015, 183036-183036 (2015-05-20)
The extracts of 14 Julianaceae and 5 Clusiaceae species growing in Mexico were tested in vitro (50 µg/mL) against Mycobacterium tuberculosis H37Rv and HIV reverse transcriptase (HIV-RT). The Julianaceae bark and leaf extracts inhibited M. tuberculosis (>84.67%) and HIV-RT (<49.89%). The...
The uptake of dissolved organic material by the sea cucumber Parastichopus californicus (Stimpson) and its potential role in visceral regeneration.
Brothers CJ, et al.
Journal of Experimental Marine Biology and Ecology, 469, 69-75 (2015)
Zeljka Korade et al.
Biological psychiatry, 75(3), 215-222 (2013-07-31)
Smith-Lemli-Opitz syndrome (SLOS) is an inborn error of cholesterol biosynthesis characterized by diminished cholesterol and increased 7-dehydrocholesterol (7-DHC) levels. 7-Dehydrocholesterol is highly reactive, giving rise to biologically active oxysterols. 7-DHC-derived oxysterols were measured in fibroblasts from SLOS patients and an...
Miriam Carr et al.
European journal of medicinal chemistry, 45(12), 5752-5766 (2010-10-12)
The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products....