Skip to Content
Merck
All Photos(3)

Key Documents

View All Documentation

Safety Information

27815

Sigma-Aldrich

p-Toluenesulfonic acid monohydrate

≥99% (calc. to H2O free subst.)

Synonym(s):

4-Methylbenzenesulfonic acid monohydrate, 4-Toluenesulfonic acid monohydrate, PTSA monohydrate, TsOH monohydrate

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Linear Formula:
CH3C6H5SO3H · H2O
CAS Number:
6192-52-5
Molecular Weight:
190.22
Colour Index Number:
42655
Beilstein:
3568023
EC Number:
203-180-0
MDL number:
MFCD00142137
UNSPSC Code:
12352106
PubChem Substance ID:
57648235
NACRES:
NA.22

Quality Level

200

Assay

≥99% (calc. to H2O free subst.)

form

solid

impurities

≥85% toluene-4-solfonic acid
8-12% water (Karl Fischer)

ign. residue

≤0.5%

SMILES string

O.Cc1ccc(cc1)S(O)(=O)=O

InChI

1S/C7H8O3S.H2O/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);1H2

InChI key

KJIFKLIQANRMOU-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy-to-handle organic catalyst used in organic synthesis.

Application

p-Toluenesulfonic acid monohydrate is a catalyst in esterification, reductive amination, Biginelli reaction, and intermolecular coupling of the aromatic nucleus. It is also used in the preparation of various bioactive compounds via multicomponent condensation reactions.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1C - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

27815-1KG-R:4548174005781
27815-6X1KG-R:
27815-25KG-R:
27815-2.5KG-R:4548174005798
27815-6X2.5KG-R:
27815S-25KG-R:
27815-BULK-R:
27815-VAR-R:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
STBK3427
STBK3426
BCCF5776
STBJ8961
STBJ6078

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

4-Toluenesulfonamide for synthesis

Sigma-Aldrich

8.08230

4-Toluenesulfonamide

P P Akalin et al.
Polish journal of veterinary sciences, 22(2), 271-278 (2019-07-04)
This study aimed to determine the levels of milk cell total protein (TP), reduced nicotinamide adenine dinucleotide phosphate (NADPH), total glutathione (tGSH), activities of glucose-6-phosphate dehydrogenase (G6PD) and glutathione peroxidase (GPx) in subclinical mastitic cows. Milk from each udder was
Juan Mauricio Garré et al.
Nature communications, 11(1), 1784-1784 (2020-04-15)
Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with pro-inflammatory functions. Here, we report in a
Ashleigh Willis et al.
Journal of neuroscience methods, 308, 1-5 (2018-07-24)
Primary neuronal cultures underpin diverse neuroscience experiments, including various protein analysis techniques, such as Western blotting, whereby protein extraction from cultured neurons is required. During immunoblotting experiments, we encountered problems due to a highly-abundant protein of 65-70 KDa present in
Ayman M Atta et al.
Molecules (Basel, Switzerland), 20(6), 11131-11153 (2015-06-20)
This work examines the use of new hydrophobic ionic liquid derivatives, namely octadecylammonium tosylate (ODA-TS) and oleylammonium tosylate (OA-TS) for corrosion protection of steel in 1 M hydrochloric acid solution. Their chemical structures were determined from NMR analyses. The surface
Yi-Ling Hsieh et al.
Pharmaceutical research, 32(9), 3110-3118 (2015-04-16)
The aim of this study was to investigate how the disproportionation process can be impacted by the properties of the salt, specifically pHmax. Five miconazole salts and four sertraline salts were selected for this study. The extent of conversion was
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service