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263389

Sigma-Aldrich

3,5-Bis(trifluoromethyl)benzylamine

technical grade, 80%

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About This Item

Linear Formula:
(CF3)2C6H3CH2NH2
CAS Number:
85068-29-7
Molecular Weight:
243.15
Beilstein:
7209267
EC Number:
285-290-9
MDL number:
MFCD00009909
UNSPSC Code:
12352100
PubChem Substance ID:
24855967
NACRES:
NA.22

grade

technical grade

Quality Level

100

Assay

80%

form

solid

mp

50-55 °C (lit.)

functional group

amine
fluoro

SMILES string

NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI

1S/C9H7F6N/c10-8(11,12)6-1-5(4-16)2-7(3-6)9(13,14)15/h1-3H,4,16H2

InChI key

DHVHORCFFOSRBP-UHFFFAOYSA-N

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Application

3,5-Bis(trifluoromethyl)benzylamine has been used in the preparation of phenyl glycine derivatives.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

172.4 °F - closed cup

Flash Point(C)

78 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

263389-BULK:
263389-VAR:
263389-5G:
263389-1G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ3038
MKCL6589
MKCJ8967
MKCH0686
MKCF4699

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Lihu Yang et al.
Bioorganic & medicinal chemistry letters, 16(14), 3735-3739 (2006-05-16)
Systematic modification of a screening lead yielded a class of potent glycinamide based CCR2 antagonists. The best compound (55, (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-{[2-(1-piperidinyl)ethyl]amino}-2-(3-thienyl)acetamide) displayed good binding affinity (IC50=30 and 39 nM) toward human monocytes and CHO cell expressing human CCR2b, respectively. Functionally, it

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