260428

3-Ethoxy-1,2-propanediol

98%

• Synonym(s): 3-Ethoxypropane-1,2-diol, Glycerol 1-ethyl ether
• Linear Formula: C₂H₅OCH₂CH(OH)CH₂OH
• CAS Number: 1874-62-0
• Molecular Weight: 120.15
• EC Number: 217-503-8
• MDL number: MFCD00009989
• UNSPSC Code: 12162002
• PubChem Substance ID: 24855753
• NACRES: NA.23

Properties

• Quality Level: 100
• Assay: 98%
• form: liquid
• refractive index: n20/D 1.441 (lit.)
• bp: 222 °C (lit.)
• density: 1.063 g/mL at 25 °C (lit.)
• SMILES string: CCOCC(O)CO
• InChI: 1S/C5H12O3/c1-2-8-4-5(7)3-6/h5-7H,2-4H2,1H3
• InChI key: LOSWWGJGSSQDKH-UHFFFAOYSA-N

Description

General description

3-Ethoxy-1,2-propanediol (also known as glycerol α-ethyl ether) is primarily used as a solvent in various industries, including pharmaceuticals, cosmetics, and coatings. It can also be used as a substrate in the synthesis of cyclic phosphates for use in flame retardants.

Application

3-Ethoxy-1,2-propanediol (EGE) can be used as a crosslinking agent in the development of poly(glycidol) hydrogels for use in various biomedical applications such as tissue engineering and drug delivery. It is also used as a potential component in a bio-based solvent system for dissolving or processing nitrocellulose.

3-Ethoxy-1,2-propanediol can be used as:

• An analyte protector in gas chromatographic analysis of pesticides.
• An acceptor substrate in glycosylation reaction by sucrose phosphorylase.

It can also be used as a precursor in the Mitsunobu reaction of N-hydroxy phthalimide with poly(glycidol) and synthesis of 2-(3-ethoxy-2-hydroxypropoxy) isoindoline-1,3-dione.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315
• Precautionary Statements: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves