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256226

Sigma-Aldrich

N,N-Dimethyloctylamine

95%

Synonym(s):

1-(Dimethylamino)octane, N-Octyldimethylamine, Adma 8, DMOA

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About This Item

Linear Formula:
CH3(CH2)7N(CH3)2
CAS Number:
7378-99-6
Molecular Weight:
157.30
Beilstein:
1698081
EC Number:
230-939-3
MDL number:
MFCD00009558
UNSPSC Code:
12352100
PubChem Substance ID:
24855508
NACRES:
NA.22

vapor density

5.4 (vs air)

Quality Level

200

vapor pressure

0.8 mmHg ( 25 °C)

Assay

95%

form

liquid

refractive index

n20/D 1.424 (lit.)

bp

195 °C (lit.)

mp

−57 °C (lit.)

density

0.765 g/mL at 25 °C (lit.)

SMILES string

CCCCCCCCN(C)C

InChI

1S/C10H23N/c1-4-5-6-7-8-9-10-11(2)3/h4-10H2,1-3H3

InChI key

UQKAOOAFEFCDGT-UHFFFAOYSA-N

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Application

N,N-Dimethyloctylamine has been employed:
  • as ion-pairing agent in quantitative estimation of thiazinamium methylsulphate in a pharmaceutical preparation by HPLC
  • as counterion in mobile phase for separation of tetracycline, tetracycline analogs and their potential impurities by reversed-phase ion-pair chromatography
  • as mobile phase in direct resolution and quantitation of (R)- and (S)-disopyramide in human plasma
  • in study of chiral separations by complexation with proteins in capillary zone electrophoresis

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

156.2 °F - closed cup

Flash Point(C)

69 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Hermansson et al.
Journal of pharmaceutical sciences, 71(2), 222-229 (1982-02-01)
Methods are presented for the separation of tetracycline, tetracycline analogs, and their potential impurities by reversed-phase ion-pair chromatography. The mobile phase consisted of a phosphate buffer with tripropylamine or N,N-dimethyloctylamine as counterions and acetonitrile as the organic modifier. The chromatographic
J Hermansson et al.
Journal of chromatography, 336(2), 321-328 (1984-12-12)
The direct resolution and quantitation of (R)- and (S)-disopyramide, isolated from human plasma, was accomplished using a chiral alpha 1-acid glycoprotein column. A LiChrosorb RP-2 column (50 X 3.0 mm I.D.) was used as a precolumn. Phosphate buffer, pH 6.20
E Smet et al.
Journal of pharmaceutical and biomedical analysis, 23(1), 175-183 (2000-07-18)
The phenothiazine derivative thiazinamium methylsulphate is a drug with antihistaminic and anticholinergic properties, often used in some types of obstructive lung diseases. Because there is a lack of chromatographic data available for its determination, the objective of the present investigation
Journal of Chromatography A, 635, 119-119 (1993)
T T Nikiforov et al.
Analytical biochemistry, 227(1), 201-209 (1995-05-01)
A reliable, simple, and cost-effective method for the immobilization of relatively short (12-30 mer) oligonucleotide probes to 96-well polystyrene plates was required in our laboratory for use in DNA hybridization-based assays. We compared three different approaches to achieve this immobilization.
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