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Safety Information

228052

Sigma-Aldrich

Methylphosphonic dichloride

98%

Synonym(s):

Dichloromethylphosphine oxide, Methanephosphonyl chloride, Methylphosphonodichloridic acid, Methylphosphonyl chloride, Methylphosphonyl dichloride

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About This Item

Linear Formula:
CH3P(O)Cl2
CAS Number:
676-97-1
Molecular Weight:
132.91
Beilstein:
1071305
EC Number:
211-634-4
MDL number:
MFCD00002071
UNSPSC Code:
12352101
PubChem Substance ID:
24853672
NACRES:
NA.22

vapor pressure

760 mmHg ( 163 °C)

Assay

98%

form

solid

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

bp

163 °C (lit.)

mp

35-37 °C

density

1.468 g/mL at 25 °C (lit.)

SMILES string

CP(Cl)(Cl)=O

InChI

1S/CH3Cl2OP/c1-5(2,3)4/h1H3

InChI key

SCLFRABIDYGTAZ-UHFFFAOYSA-N

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Application

Undergoes condensation reactions with aminobenzenes and alcohols.

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H314,H330

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Corr. 1B

Supplementary Hazards

EUH014

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

228052-1G:4548173120034
228052-5G:4548173120058
228052-25G:4548173120041
228052-BULK:
228052-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCK5628
MKCH8639
MKCF6496
MKCB1826V
MKBV0016V

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Synthetic Communications, 23, 2273-2273 (1993)
Helvetica Chimica Acta, 75, 2520-2520 (1992)
Yasuo Seto et al.
Journal of chromatography. A, 1501, 99-106 (2017-04-25)
A target analysis method for the sensitive and discriminative determination of the nerve agent hydrolysis products alkyl methylphosphonic acids as their tert-butyldimethylsilyl (TBDMS) derivatives was developed using a combination of selectable one- and two-dimensional (
J Rahil et al.
Biochemistry, 32(40), 10763-10772 (1993-10-12)
Four phosphonamidates were synthesized as potential beta-lactamase inhibitors. Three were methanephosphonamidates [CH3PO2-NHR/Ar, where R/Ar = 4-methoxybenzyl (3a), phenyl (3b), and m-nitrophenyl (3c)], while the fourth, PhCH2OCONHCH2PO2-NHPh (2a), also contained a beta-lactamase active site-directed amido side chain. The pH-rate profiles for
Tomohide Kondo et al.
Forensic science international, 291, 23-38 (2018-08-21)
The Raman spectra of twenty-two chemical warfare agents (CWAs) were measured: eleven nerve agents and their precursor, five blister agents, three lachrymators, one choking agent, and one vomit agent, in liquid or solid state in colorless transparent vials were analyzed

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