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20615

Sigma-Aldrich

2-tert-Butyl-1,1,3,3-tetramethylguanidine

≥97.0% (GC)

Synonym(s):

BTMG

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About This Item

Empirical Formula (Hill Notation):
C9H21N3
CAS Number:
29166-72-1
Molecular Weight:
171.28
Beilstein:
2352408
MDL number:
MFCD01862972
UNSPSC Code:
12352100
PubChem Substance ID:
57647848
NACRES:
NA.22

Quality Level

200

Assay

≥97.0% (GC)

form

liquid

refractive index

n20/D 1.457

bp

88-89 °C/43 mmHg (lit.)

SMILES string

CN(C)\C(=N/C(C)(C)C)N(C)C

InChI

1S/C9H21N3/c1-9(2,3)10-8(11(4)5)12(6)7/h1-7H3

InChI key

YQHJFPFNGVDEDT-UHFFFAOYSA-N

General description

2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

Application

  • Synthesis of dinaphthyl ethers: Barton′s base, which includes 2-tert-Butyl-1,1,3,3-tetramethylguanidine, was utilized to promote SNAr reactions for the synthesis of highly oxygenated dinaphthyl ethers, demonstrating its efficacy as a catalyst in complex organic synthesis processes (Wipf and Lynch, 2003).

Caution

Remark on appearance: Material may form precipitate on storage. The precipitate may easily be separated by filtration.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

149.0 °F - closed cup

Flash Point(C)

65.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

20615-BULK:
20615-INTR:
20615-5ML:
20615-25ML:
20615-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG1226
BCCG0538
BCCG0142
BCCF9837
BCCF8853

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D.H.R. Barton et al.
Organic Syntheses, 74, 103-103 (1997)
Peter Wipf et al.
Organic letters, 5(7), 1155-1158 (2003-03-28)
[reaction: see text] Electron-rich dinaphthyl ethers were synthesized by S(N)Ar reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

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