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Safety Information

171468

Sigma-Aldrich

Perfluorooctanoic acid

95%

Synonym(s):

Pentadecafluorooctanoic acid, PFOA, Perfluorocaprylic acid, Perfluorooctanoic acid

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About This Item

Linear Formula:
CF3(CF2)6COOH
CAS Number:
335-67-1
Molecular Weight:
414.07
Beilstein:
1809678
EC Number:
206-397-9
MDL number:
MFCD00004174
UNSPSC Code:
12352211
PubChem Substance ID:
24850346
NACRES:
NA.22

Assay

95%

bp

189 °C/736 mmHg (lit.)

mp

55-56 °C (lit.)

SMILES string

OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25)

InChI key

SNGREZUHAYWORS-UHFFFAOYSA-N

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Application

PFOA, its salts and related substances are listed in Part A of Annex I of the Persistent Organic Pollutants (POPs) Regulation (EU) 2019/1021. It can only be used for Laboratory-scale research or as a reference standard

Derogations until 4 July 2025 are uses in
  • photolithography or etch processes in semiconductor manufacturing
  • photographic coatings applied to films
  • invasive and implantable medical devices
The use is further allowed in firefighting foams for Class B fires until 4 July 2025

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Corr. 1C - STOT RE 1

Target Organs

Liver

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

171468-VAR:
171468-BULK:
171468-5G:4548173986029
171468-25G:4548173986012

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD6815V
WXBD6205V
WXBD5139V
WXBD3549V
WXBD1156V

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Yusun Zhou et al.
Scientific reports, 6, 38633-38633 (2016-12-15)
Using a novel magnetic nanocomposite as adsorbent, a convenient and effective magnetic solid-phase extraction (MSPE) procedure was established for selective separation and concentration of nine perfluorinated compounds (PFCs) in surface water sample. Then an ultra high-performance liquid chromatography-tandem mass spectrometry
Lilan Zhang et al.
Environmental pollution (Barking, Essex : 1987), 229, 159-167 (2017-06-09)
With the phaseout of perfluorooctane sulfonate (PFOS) production in most countries and its well known recalcitrance, there is a need to quantify the potential release of PFOS from precursors previously or currently being emitted into the environment. Aerobic biodegradation of
Binding of perfluorooctanoic acid to rat and human plasma proteins.
Han X, et al.
Chemical Research in Toxicology, 16(6), 775-781 (2003)
Effects of perfluorooctanoic acid exposure during pregnancy in the mouse.
Lau C, et al.
Toxicological Sciences, 90(2), 510-518 (2006)
Naomi Kudo et al.
The Journal of toxicological sciences, 28(2), 49-57 (2003-06-25)
Perfluorooctanoic acid (PFOA) is an octanoic acid derivative to which all aliphatic hydrocarbons are substituted by fluorine. PFOA and its salts are commercially used in various industrial processes. The chemical is persistent in the environment and does not undergo biotransformation.
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