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Safety Information

143634

Sigma-Aldrich

p-Tolyl isocyanate

99%

Synonym(s):

4-Methylphenyl isocyanate

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About This Item

Linear Formula:
CH3C6H4NCO
CAS Number:
622-58-2
Molecular Weight:
133.15
Beilstein:
471494
EC Number:
210-743-4
MDL number:
MFCD00002029
UNSPSC Code:
12352100
PubChem Substance ID:
24848599
NACRES:
NA.22

Quality Level

100

Assay

99%

form

liquid

refractive index

n20/D 1.531 (lit.)

bp

70-72 °C/10 mmHg (lit.)

density

1.056 g/mL at 25 °C (lit.)

functional group

isocyanate

storage temp.

2-8°C

SMILES string

Cc1ccc(cc1)N=C=O

InChI

1S/C8H7NO/c1-7-2-4-8(5-3-7)9-6-10/h2-5H,1H3

InChI key

MGYGFNQQGAQEON-UHFFFAOYSA-N

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General description

p-Tolyl isocyanate reacts with human serum albumin to form antigen which helps in detecting IgE antibodies in workers hypersensitive to toluene diisocyanate.

Application

p-Tolyl isocyanate was used to study the catalytic role of supported Rhodium(I) complex toward the reductive carbonylation of nitrobenzene in DMF medium.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

150.8 °F - closed cup

Flash Point(C)

66 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

143634-100G:
143634-VAR:
143634-BULK:
143634-25G:
143634-5G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8203
MKCQ3895
MKCN7841
MKCN6324
MKCN4946

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J M Danks et al.
Clinical allergy, 11(2), 161-168 (1981-03-01)
Radioallergosorbent testing was used to look for the presence of specific IgE antibody against a para-tolyl-mono-isocyanate human serum albumin conjugate in sera from five groups of subjects. The first three groups consisted of individuals exposed to toluene diisocyanate (TDI) who
B T Butcher et al.
The Journal of allergy and clinical immunology, 70(4), 231-235 (1982-10-01)
Toluene diisocyanate (TDI) sensitivity accompanied by nonspecific bronchial hyperresponsiveness occurs in approximately 5% of occupationally exposed workers. We report the case of a 32-yr-old worker followed longitudinally after removal from isocyanate exposure. TDI reactivity was lost 11 mo after removal
C J Game
American Industrial Hygiene Association journal, 43(10), 759-763 (1982-10-01)
Sera of 91 people were assayed for IgE which bound to a p-tolyl-isocyanate-human serum albumin conjugate. The sera came from 20 blood donors, 70 factory workers, and 1 casualty patient. Three factory workers had abnormally high assay values in association
B T Butcher et al.
Clinical allergy, 13(1), 31-34 (1983-01-01)
Sera from 149 occupationally exposed toluene diisocyanate (TDI) workers were tested by RAST with p-tolyl monoisocyanate human serum albumin (TMI-HSA). Of the seven positives, one had a history suggestive of TDI asthma and one had a rash which may have
K C Chang et al.
Clinical allergy, 14(4), 329-339 (1984-07-01)
A worker developed two episodes of severe asthma 90 min after cutting a polyurethane plate made of diphenylmethane diisocyanate (MDI) using a rapidly turning carbide blade. Intradermal skin testing with MDI-human serum albumin (MDI-HSA) and p-tolyl isocyanate-HSA (p-TMI-HSA) were positive
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