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127485

Sigma-Aldrich

5-Chloro-2-oxindole

98%

Synonym(s):

5-Chlorooxindole

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About This Item

Empirical Formula (Hill Notation):
C8H6ClNO
CAS Number:
17630-75-0
Molecular Weight:
167.59
EC Number:
412-200-9
MDL number:
MFCD00191927
UNSPSC Code:
12352100
PubChem Substance ID:
24847781
NACRES:
NA.22

Quality Level

100

Assay

98%

form

solid

mp

194-197 °C (lit.)

solubility

methanol: soluble 2.5 mL, clear

functional group

chloro

SMILES string

Clc1ccc2NC(=O)Cc2c1

InChI

1S/C8H6ClNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)

InChI key

WWJLCYHYLZZXBE-UHFFFAOYSA-N

Related Categories

General description

5-Chloro-2-oxindole (5-Chlorooxindole) is a starting material for tenidap sodium, a pharmaceutical drug candidate.

Application

5-Chloro-2-oxindole was used for the quantitation of 5-chloro-2-oxindole, concomitantly with all of its potential positional isomers using a single, highly specific, normal-phase chromatographic system.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H317,H361f,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

127485-BULK:
127485-1G:
127485-5G:
127485-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
07928TD
10623EQ
09822CF
04229HN
01906JS

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S T Colgan et al.
Journal of pharmaceutical and biomedical analysis, 14(7), 825-833 (1996-05-01)
5-Chlorooxindole (5-CO) is a starting material for tenidap sodium, a pharmaceutical drug candidate produced by Pfizer. To insure potency and purity of the drug substance, it is necessary to demonstrate that commercial supplies of 5-CO are free from elevated levels
Boris Letribot et al.
Molecules (Basel, Switzerland), 23(6) (2018-06-13)
Alkylidene oxindoles are important functional moieties and building blocks in pharmaceutical and synthetic chemistry. Our interest in biologically active compounds focused our studies on the synthesis of novel oxindoles, bearing on the exocyclic double bond at the C8, CN, and
Ayman M Saleh et al.
Molecules (Basel, Switzerland), 19(9), 13076-13092 (2014-08-27)
A selected set of substituted pyridone-annelated isoindigos 3a-f has been synthesized via interaction of 5- and 6-substituted oxindoles 2a-f with 6-ethyl-1,2,9-trioxopyrrolo[3,2-f]quinoline-8-carboxylic acid (1) in acetic acid at reflux. Among these isoindigos, the 5'-chloro and 5'-bromo derivatives 3b and 3d show

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