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Safety Information

113727

Sigma-Aldrich

Norphenylephrine hydrochloride

98%

Synonym(s):

α-Aminomethyl-3-hydroxybenzyl alcohol hydrochloride, 3,α-Dihydroxyphenethylamine hydrochloride, Norfenefrine hydrochloride

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About This Item

Linear Formula:
HOC6H4CH(CH2NH2)OH · HCl
CAS Number:
4779-94-6
Molecular Weight:
189.64
EC Number:
225-323-6
MDL number:
MFCD00012879
UNSPSC Code:
12352100
PubChem Substance ID:
24847145
NACRES:
NA.22

Quality Level

100

Assay

98%

form

solid

mp

162-164 °C (lit.)

functional group

amine
hydroxyl

SMILES string

Cl.NCC(O)c1cccc(O)c1

InChI

1S/C8H11NO2.ClH/c9-5-8(11)6-2-1-3-7(10)4-6;/h1-4,8,10-11H,5,9H2;1H

InChI key

OWMFSWZUAWKDRR-UHFFFAOYSA-N

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Application

Norphenylephrine hydrochloride was used in the study of the effects of phenylephrine on the isolated heart of rabbit.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

113727-VAR:
113727-10G:
113727-250G:
113727-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG4067
BCBZ3989
BCBP2130V
STBD4364V
STBC5621V

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H G Zimmer
Journal of molecular medicine (Berlin, Germany), 75(11-12), 849-859 (1998-01-15)
The effect of beta- and alpha-adrenergic stimulation on cardiovascular function and development of cardiac hypertrophy was studied in rats by measuring the heart weight/body weight and cardiac RNA/DNA ratios. Beta-receptor stimulation with isoproterenol over 3 days induced an increase in
Yan Gao et al.
Electrophoresis, 29(9), 1918-1923 (2008-04-04)
This study presents a four-channel electrophoresis chip platform, featuring double-cross hydrostatic sample injection, for rapid chiral selector screening. This platform needs only five electrodes to drive microchip electrophoresis in four separate channels for screening four chiral selectors at a time.
P J Fletcher et al.
British journal of pharmacology, 97(2), 483-489 (1989-06-01)
1. The effects on food intake in rats of injection of m- and p-octopamine into the paraventricular nucleus (PVN) of the hypothalamus were examined, and compared to the effects of noradrenaline (NA). 2. m-Octopamine injected into the PVN induced a
B G Benfey
British journal of pharmacology, 48(1), 132-138 (1973-05-01)
1. In the driven rabbit left atrium alpha-adrenoceptors mediate the inotropic effect of phenylephrine and the prolongation of functional refractory period by sympathomimetic amines.2. These receptors are highly sensitive to blockade by phentolamine and phenoxybenzamine.3. Prolongation of functional refractory period
J C David et al.
Journal of neurochemistry, 53(1), 149-154 (1989-07-01)
Functions of octopamine in the mammalian brain are still not well known. An important aspect of this problem is the relationship between octopamines and catecholamines. Previous data have shown that their respective ontogenic evolutions are not parallel. Do the changes
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