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108456

Sigma-Aldrich

Trimethyl orthoformate

99%

Synonym(s):
Trimethoxymethane
Linear Formula:
CH(OCH3)3
CAS Number:
Molecular Weight:
106.12
Beilstein:
969215
EC Number:
MDL number:
eCl@ss:
39021015
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.67 (vs air)

Quality Level

vapor pressure

23.5 mmHg ( 20 °C)
40 mmHg ( 30 °C)
57 mmHg ( 40 °C)

Assay

99%

expl. lim.

5.1 %

refractive index

n20/D 1.379 (lit.)

bp

101-102 °C (lit.)

density

0.97 g/mL at 25 °C (lit.)

SMILES string

COC(OC)OC

InChI

1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3

InChI key

PYOKUURKVVELLB-UHFFFAOYSA-N

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1 of 4

This Item
305472164534254517
vapor pressure

23.5 mmHg ( 20 °C)

vapor pressure

23.5 mmHg ( 20 °C), 40 mmHg ( 30 °C), 57 mmHg ( 40 °C)

vapor pressure

-

vapor pressure

-

assay

99%

assay

99.8%

assay

98%

assay

97%

expl. lim.

5.1 %

expl. lim.

5.1 %

expl. lim.

-

expl. lim.

-

refractive index

n20/D 1.379 (lit.)

refractive index

n20/D 1.379 (lit.)

refractive index

n20/D 1.489 (lit.)

refractive index

n20/D 1.410 (lit.)

bp

101-102 °C (lit.)

bp

101-102 °C (lit.)

bp

87-88 °C/7 mmHg (lit.)

bp

164-166 °C (lit.)

General description

Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.

Application

Trimethyl orthoformate was used as dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

55.4 °F - closed cup

Flash Point(C)

13 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names


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Thallium in organic synthesis. 43. Novel oxidative rearrangements with thallium (III) nitrate (TTN) in trimethyl orthoformate (TMOF).
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Journal of the American Chemical Society, 98(10), 3037-3038 (1976)
P F Holmes et al.
Journal of biomedical materials research. Part A, 91(3), 824-833 (2008-12-04)
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Synthesis of 8-demethyl-8-hydroxy-5-deazariboflavins
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Journal of Heterocyclic Chemistry, 17(8), 1709-1712 (1980)
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