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Safety Information

105120

Sigma-Aldrich

2-Bromo-2′-acetonaphthone

99%

Synonym(s):

Bromomethyl 2-naphthyl ketone

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About This Item

Linear Formula:
C10H7COCH2Br
CAS Number:
613-54-7
Molecular Weight:
249.10
EC Number:
210-348-7
MDL number:
MFCD00004109
UNSPSC Code:
12352100
PubChem Substance ID:
24846689
NACRES:
NA.22

Quality Level

100

Assay

99%

mp

82-84 °C (lit.)

solubility

acetonitrile: soluble

functional group

bromo
ketone

SMILES string

BrCC(=O)c1ccc2ccccc2c1

InChI

1S/C12H9BrO/c13-8-12(14)11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8H2

InChI key

YHXHHGDUANVQHE-UHFFFAOYSA-N

Gene Information

human ... PTPN6(5777)

General description

2-Bromo-2′-acetonaphthone is used for derivatization of captopril to develop a fast and sensitive high-performance liquid chromatographic method for the determination of captopril in plasma.2-Bromo-2′-acetonaphthone converts tetra-acids extracted from calcium naphthenate deposits to 2-naphthacyl derivatives.

Application

2-Bromo-2′-acetonaphthone was used to determine the concentration of tetra-acids in calcium naphthenate deposits. 2-Bromo-2′-acetonaphthone was used as derivation reagent for determination of fatty acids extracted from Botryococcus braunii by HPLC.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Irrit. 2 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

105120-5G:
105120-BULK:
105120-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN3885
MKCC6921
MKBZ5836V
MKBS3866V
MKBD0726V

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Jia-You Fang et al.
International journal of pharmaceutics, 276(1-2), 163-173 (2004-04-29)
To improve the drug absorption into and across the skin, fatty acids extracted from Botryococcus braunii were evaluated using in vitro and in vivo techniques with Wistar rats as the animal model. Palmitic acid (C16:0), oleic acid (C18:1), linoleic acid
Sébastien Simon et al.
Journal of chromatography. A, 1200(2), 136-143 (2008-06-17)
A method is described which allows to determine the content of the so-called C(80) tetra-acid molecules (TA) in calcium naphthenate deposits. The method consists of four steps. Molecules present in the deposit are dissolved in a mixture of toluene and
M Amini et al.
Pharmaceutica acta Helvetiae, 73(6), 303-306 (1999-08-12)
A rapid, simple and sensitive high-performance liquid chromatographic method for the determination of captopril in plasma has been developed. Captopril is derivatized with a new reagent, 2-bromo-2'-acetonaphthone to form a product that showed ultraviolet-absorbing properties. For plasma samples, the protein

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