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  • A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C-H functionalization.

A concise and scalable strategy for the total synthesis of dictyodendrin B based on sequential C-H functionalization.

Angewandte Chemie (International ed. in English) (2015-02-24)
Andrew K Pitts, Fionn O'Hara, Robert H Snell, Matthew J Gaunt
ABSTRACT

A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product.

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Sigma-Aldrich
4-Bromoindole, 96%