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  • An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines.

An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2002-10-24)
Margarita Vlachou, Andrew Tsotinis, Lloyd R Kelland, David E Thurston
ABSTRACT

A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two of the new compounds, 7c and 7d, are selective toward the A2780 cisplatin-resistant line.

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Sigma-Aldrich
5-Nitroisoquinoline, 98%