12034AST
Astec® CHIROBIOTIC® T Chiral (5 μm) HPLC Columns
L × I.D. 25 cm × 10 mm, HPLC Column
Sinonimo/i:
CHIROBIOTIC T Column
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About This Item
Codice UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Prodotti consigliati
Nome del prodotto
Colonna HPLC chirale Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 25 cm × 10 mm
Materiali
stainless steel column
agenzia
suitable for USP L63
Descrizione
HPLC column
Nome Commerciale
Astec®
Confezionamento
pkg of 1 ea
Produttore/marchio commerciale
Astec®
Parametri
0-45 °C temperature
241 bar pressure (3500 psi)
tecniche
HPLC: suitable
LC/MS: suitable
Lungh. × D.I.
25 cm × 10 mm
Matrice
High-purity silica gel particle platform
fully porous particle
Gruppo funzionale matrice
teicoplanin glycopeptide phase
Dimensione particelle
5 μm
Dimensione pori
100 Å
Intervallo di pH d’impiego
3.8-6.8
Tecnica di separazione
chiral
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Descrizione generale
CHIROBIOTIC® T e T2 hanno come selettore chirale la teicoplanina. Offrono una selettività unica per numerose classi di molecole, aminoacidi specificamente non derivatizzati α, β, γ e ciclici, aminoacidi N-derivatizzati, acidi idrossi-carbossilici, composti acidi inclusi gli acidi carbossilici e i fenoli, piccoli peptidi, analiti aromatici neutri e aromatici ciclici e ammine alifatiche. Separazioni che di solito si ottengono su un etere corona chirale o CSP del tipo a scambio di ligandi sono possibili anche sui CHIROBIOTIC® T e T2, ma in fasi mobili molto più semplici, come acqua-alcol. Sono stati inoltre risolti tutti i betabloccanti (amminoalcol) noti e le diidrocumarine. CHIROBIOTIC® T e T2 differiscono nella chimica di legame e nella dimensione dei pori della particella di supporto, presentando quindi selettività e capacità preparative differenti.
FAQ sui prodotti CHIROBIOTIC
Bibliografia di riferimento sui prodotti CHIROBIOTIC
Articoli sui prodotti chirali
- Fase legata: teicoplanina
- Intervallo operativo di pH: 3,8 - 6,8
- Diametro delle particelle: 5, 10 or 16 μm
- Dimensione dei pori: 100 Å (CHIROBIOTIC® T) o 200 Å (CHIROBIOTIC® T2)
FAQ sui prodotti CHIROBIOTIC
Bibliografia di riferimento sui prodotti CHIROBIOTIC
Articoli sui prodotti chirali
Applicazioni
- Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples.: This study outlines the development of a chiral LC-MS/MS method utilizing the Astec® CHIROBIOTIC® T Chiral HPLC Column for detecting salbutamol enantiomers in urine, showcasing its application in doping control and analytical chemistry. The research demonstrates the column′s capability for precise and selective measurement of chiral molecules in complex biological matrices (Chan et al., 2016).
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: Highlighting the versatility of Astec® CHIROBIOTIC® T Chiral HPLC Column, this paper details the enantioseparation of cyclic amino acids critical for the development of new pharmaceuticals and biochemical studies. The column′s effectiveness in resolving complex chiral acids reinforces its importance in pharmaceutical research and chiral chemical analysis (Berkecz et al., 2009).
Note legali
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Felikss Mutulis et al.
Bioorganic & medicinal chemistry, 15(17), 5787-5810 (2007-07-10)
Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff
Balázs Visegrády et al.
Journal of biochemical and biophysical methods, 53(1-3), 15-24 (2002-10-31)
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out
Mohamed M Hefnawy et al.
Talanta, 61(5), 667-673 (2008-10-31)
A new analytical method for the separation and determination of R-(-)- and S-(+)- baclofen enantiomers in human plasma by high-performance liquid chromatography (HPLC) with UV detection was developed. Enantioselective resolution of the baclofen enantiomers was achieved by using teicoplanin macrocyclic
Zahid Ali et al.
Journal of chromatography. A, 1052(1-2), 199-204 (2004-11-06)
The solvation parameter model is used to characterize the retention properties of a 3-aminopropylsiloxane-bonded (Alltima amino), three 3-cyanopropylsiloxane-bonded (Ultrasphere CN, Ultremex-CN and Zorbax SB-CN), a spacer bonded propanediol (LiChrospher DIOL) and a multifunctional macrocyclic glycopeptide (Chirobiotic T) silica-based stationary phases
M Sanghvi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 933, 37-43 (2013-07-23)
Due to the lack of sensitivity in current methods for the determination of fenoterol (Fen), a rapid LC-MS/MS method was developed for the determination of (R,R')-Fen and (R,R';S,S')-Fen in plasma and urine. The method was fully validated and was linear
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