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Merck
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Key Documents

Altri documenti

UC148

Sigma-Aldrich

6-Hydroxychlorzoxazone

≥98% (HPLC)

Sinonimo/i:

5-Chloro-6-hydroxy-2(3H)-benzoxazolone, 5-Chloro-6-hydroxybenzoxazone

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About This Item

Formula empirica (notazione di Hill):
C7H4ClNO3
Numero CAS:
1750-45-4
Peso molecolare:
185.56
Numero MDL:
MFCD00143502
Codice UNSPSC:
12161501
ID PubChem:
24724641

Livello qualitativo

200

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white to pink

Solubilità

methanol: soluble

Temperatura di conservazione

2-8°C

Stringa SMILE

Oc1cc2OC(=O)Nc2cc1Cl

InChI

1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
AGLXDWOTVQZHIQ-UHFFFAOYSA-N

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Applicazioni

6-Hydroxychlorzoxazone has been used for HPLC-based metabolic assays of chlorzoxazone.
6-hydroxy Chlorzoxazone has been used: as a reference standard to monitor substrate depletion or 6-hydroxy chlorzoxazone formation by cytochrome P450 family 2 subfamily E member 1 (CYP2E1)in recombinant human enzyme screening. 6-Hydroxychlorzoxazone has been used for high-performance liquid chromatography (HPLC)-based metabolic assays of chlorzoxazone.
CYP2E1 & 1A2 metabolite of chlorzoxazone.

Azioni biochim/fisiol

6-hydroxy Chlorzoxazone is a novel metabolite of chlorzoxazone. It is formed by the hydroxylation of chlorzoxazone by cytochrome P450 family 2 subfamily E member 1 (CYP2E1) enzyme. The determination of formation and clearance of 6-hydroxychlorzoxazone is used as a reliable marker of CYP2E1 metabolic activity.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota sulla preparazione

6-Hydroxychlorzoxazone is soluble in methanol.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 - H315 - H319 - H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Drug Metabolism in Chronic Kidney Disease
Chronic Renal Disease, 1035-1051 (2020)
In vitro CYP/FMO Reaction Phenotyping
Optimization in Drug Discovery: In Vitro Methods, 137-169 (2014)
Yang Li et al.
Pharmaceutical biology, 58(1), 695-700 (2020-07-17)
Lysionotin, a major extraction of Lysionotus pauciflorus Maxim (Gesneriaceae), has a variety of pharmacological properties commonly used in the treatment of lung disease. A study of lysionotin on the activity of human liver cytochrome P450 (CYP) enzymes can provide guidance
Choong Y Ahn et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1233-1241 (2008-04-02)
Protein expression of the hepatic CYP2E1 has been reported to be increased in diabetic rats. This enzyme is the primary metabolizer of chlorzoxazone (CZX) to 6-hydroxychlorzoxazone (OH-CZX). Although patients with liver cirrhosis have a higher prevalence of diabetes mellitus, there
Anna M Lee et al.
European journal of pharmacology, 552(1-3), 151-158 (2006-10-20)
Cytochrome P450 2E1 (CYP2E1) is expressed in the brain and liver, and can metabolize clinical drugs and activate toxins. The effect of phenobarbital on hepatic and brain CYP2E1 is unclear. We investigated the effect of chronic phenobarbital treatment on in
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