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Altri documenti

T0667

Sigma-Aldrich

Trimethoprim lactate salt

≥98%

Sinonimo/i:

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt

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About This Item

Formula empirica (notazione di Hill):
C14H18N4O3 · C3H6O3
Numero CAS:
23256-42-0
Peso molecolare:
380.40
Numero CE:
245-533-1
Numero MDL:
MFCD00171722
Codice UNSPSC:
51101500
ID PubChem:
329826610
NACRES:
NA.85

Livello qualitativo

200

Saggio

≥98%

Forma fisica

powder

Condizioni di stoccaggio

(Keep container tightly closed in a dry and well-ventilated place.)

Colore

white

Solubilità

H2O: soluble 20 mg/mL

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modalità d’azione

DNA synthesis | interferes
enzyme | inhibits

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
IIZVTUWSIKTFKO-UHFFFAOYSA-N

Categorie correlate

Descrizione generale

Chemical structure: pyrimidine

Applicazioni

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

Azioni biochim/fisiol

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 - H361d

Classi di pericolo

Acute Tox. 3 Oral - Repr. 2

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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