SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >90% (SDS-PAGE)

• Sinonimo/i: AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: mouse
• Ricombinante: expressed in HEK 293 cells
• Tag: FLAG^® tagged
• Saggio: >90% (SDS-PAGE)
• Forma fisica: liquid
• PM: ~22 kDa by SDS-PAGE
• Confezionamento: pkg of 50 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• Concentrazione: ≥0.2 mg/mL
• Impurezze: <0.1 EU/μg endotoxin, tested
• Colore: clear
• N° accesso UniProt: Q7TS55
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: mouse ... Tnfsf18(240873)

Descrizione

Descrizione generale

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Stato fisico

Solution in 10 mM glycine, pH 10.0.

Altre note

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

Note legali

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable