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Key Documents

CdO/CdA

SRP3244

IL-7 from rat

Name: IL-7 from rat
Brand: SIGMA

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sinonimo/i:

Lymphopoietin 1(LP-1), pre-B cell factor

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About This Item

Codice UNSPSC:

12352202

NACRES:

NA.32

Origine biologica

rat

Ricombinante

expressed in E. coli

Saggio

≥98% (HPLC)
≥98% (SDS-PAGE)

Forma fisica

lyophilized

Potenza

≤0.2 ng/mL ED₅₀

PM

15.0 kDa

Confezionamento

pkg of 10 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<0.1 EU/μg endotoxin, tested

Colore

white to off-white

N° accesso UniProt

P56478

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

rat ... IL7(25647)

Descrizione generale

IL-7 is a hematopoietic growth factor, which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and murine IL-7 is cross-species reactive. Recombinant rat IL-7 is a 15.0 kDa protein containing 130 amino acid residues.

Azioni biochim/fisiol

IL-7 is a hematopoietic growth factor, which affects primarily early B and T cells. Recombinant rat IL-7 is a 15.0 kDa protein containing 130 amino acid residues.

Sequenza

MDCHIKDKDG KAFGSVLMIS INQLDKMTGT DSDCPNNEPN FFKKHLCDDT KEAAFLNRAA RKLRQFLKMN ISEEFNDHLL RVSDGTQTLV NCTSKEEKTI KEQKKNDPCF LKRLLREIKT CWNKILKGSI

Stato fisico

Lyophilized from 10 mM Sodium Acetate, pH 5.8.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Spits, H.

Cytokine Reference, 137-153 (2001)

B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

A E Namen et al.

The Journal of experimental medicine, 167(3), 988-1002 (1988-03-01)

We have used a biological assay system we developed to biochemically purify a previously uncharacterized murine lymphopoietic growth factor designated lymphopoietin 1 (LP-1). This factor is capable of stimulating the proliferation and extended maintenance of precursor cells of the B

Designing the epitope flanking regions for optimal generation of CTL epitopes.

Nicholas J Steers et al.

Vaccine, 32(28), 3509-3516 (2014-05-06)

The flanking amino acids that surround epitopes are critical for effective antigen processing and maintenance of epitope integrity. In the present study, the frequency and characteristics of each amino acid that flanked the peptides generated from the proteasomal degradation of

Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission.

Antoine Chéret et al.

The Journal of antimicrobial chemotherapy, 70(7), 2108-2120 (2015-04-23)

Therapeutic control of HIV replication reduces the size of the viral reservoir, particularly among central memory CD4+ T cells, and this effect might be accentuated by early treatment. We examined the effect of ART initiated at the time of the

Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation.

Sabine Schmied et al.

Immunology, 145(4), 558-569 (2015-04-18)

The Wilms' tumour-1 (WT1) protein is considered a prime target for cancer immunotherapy based on its presumptive immunogenicity and widespread expression across a variety of malignancies. However, little is known about the naturally occurring WT1-specific T-cell repertoire because self-derived antigens

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