SRP3203
IFN-lambda 2 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinonimo/i:
IL-28A
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Origine biologica
mouse
Ricombinante
expressed in E. coli
Saggio
≥98% (HPLC)
≥98% (SDS-PAGE)
Forma fisica
lyophilized
PM
19.8 kDa
Confezionamento
pkg of 20 μg
tecniche
cell culture | mammalian: suitable
Impurezze
<0.1 EU/μg endotoxin, tested
Colore
white to off-white
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... IL28A(338374)
Azioni biochim/fisiol
IFN-λ 2 (Ifnl2) belongs to the type III interferon (IFN-λ) family of proteins. It is associated with antiviral, antitumor and immune activities. In a retinal autoimmunity mouse model, Ifnl2 increases the autoimmune disease. Ifnl2 signals via IFN (interferon)-λ receptor complex consisting of IL-10Rβ (interleukin 10 receptor β) and the IL-28Rα chains. The signaling pathway involves JAK1 (Janus kinase 1)/TYK2 (non-receptor tyrosine-protein kinase) tyrosine kinases, transcription factor complex IFN-stimulated gene factor 3 containing STAT1 (signal transducer and activator of transcription 1), STAT2 and IFN regulatory factor (IRF)-9.
Recombinant murine IFN-l2 is a 19.8kDa protein containing 175 amino acid residues.
Recombinant murine IFN-l2 is a 19.8kDa protein containing 175 amino acid residues.
Sequenza
MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV
Stato fisico
Lyophilized from 20 mM Sodium Phosphate, pH 7.5.
Ricostituzione
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma.
Lasfar A, et al.
Cancer Research, 66, 4468-4468 (2006)
Interleukin-28A enhances autoimmune disease in a retinal autoimmunity model.
Ren X, et al.
Cytokine, 70, 179-179 (2014)
An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity.
Ank N, et al.
Journal of Immunology, 180, 2474-2474 (2008)
L S Laursen et al.
FEBS letters, 504(1-2), 36-40 (2001-08-28)
Pregnancy-associated plasma protein-A (PAPP-A) has recently been identified as the proteinase responsible for cleavage of insulin-like growth factor binding protein (IGFBP)-4, an inhibitor of IGF action, in several biological fluids. Cleavage of IGFBP-4 by PAPP-A is believed to occur only
Sergei V Kotenko et al.
Nature immunology, 4(1), 69-77 (2002-12-17)
We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and
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