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SRP3195

Sigma-Aldrich

CXCL16 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sinonimo/i:

SRPSOX

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

mouse

Ricombinante

expressed in E. coli

Saggio

≥98% (HPLC)
≥98% (SDS-PAGE)

Stato

lyophilized

Potenza

20.0-1000.0 ng/mL

PM

9.9 kDa

Confezionamento

pkg of 25 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<0.1 EU/μg endotoxin, tested

Colore

off-white to yellow

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... CXCL16(66102)

Descrizione generale

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal "mucin-like stalk" sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog). Recombinant murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.

Azioni biochim/fisiol

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. Recombinant murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.

Sequenza

NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP

Stato fisico

Lyophilized from 10 mM HoAc.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Frontiers in cellular neuroscience, 8, 193-193 (2014-07-30)
Upon noxious insults, cells of the brain parenchyma activate endogenous self-protective mechanisms to counteract brain damage. Interplay between microglia and astrocytes can be determinant to build a physiological response to noxious stimuli arisen from injury or stress, thus understanding the
M Matloubian et al.
Nature immunology, 1(4), 298-304 (2001-03-23)
We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both
A Wilbanks et al.
Journal of immunology (Baltimore, Md. : 1950), 166(8), 5145-5154 (2001-04-06)
STRL33/BONZO/TYMSTR is an orphan chemokine and HIV/SIV coreceptor receptor that is expressed on activated T lymphocytes. We describe an expression cloning strategy whereby we isolated a novel chemokine, which we name CXCL16. CXCL16 is an alpha (CXC) chemokine but also
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Molecular medicine reports, 11(5), 3860-3865 (2015-01-13)
Erythropoietin (EPO) is a hematopoietic hormone that protects against renal interstitial fibrosis in animal models; however, the mechanism underlying the anti‑fibrotic activity of EPO has remained elusive. The present study aimed to elucidate this mechanism. Twenty‑four male C57BL6 mice were
Hina Mir et al.
Oncotarget, 6(12), 9985-9998 (2015-04-19)
Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor

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