SRP2067

CAR, ligand binding domain (101-348) human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• Sinonimo/i: CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• Codice UNSPSC: 12352202
• NACRES: NA.26

Proprietà

• Origine biologica: human
• Ricombinante: expressed in E. coli
• Saggio: ≥85% (SDS-PAGE)
• Forma fisica: frozen liquid
• PM: ~30 kDa
• Confezionamento: pkg of 10 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• Concentrazione: 500 μg/mL
• Colore: clear; colorless
• N° accesso NCBI: NM_005122
• N° accesso UniProt: Q14994
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... NR1I3(9970)

Descrizione

Azioni biochim/fisiol

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by `phenobarbitol-like` compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Stato fisico

Clear and colorless frozen liquid solution

Nota sulla preparazione

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable