SRP0720

SBK1, Active

PRECISIO^® Kinase, recombinant

• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Ricombinante: expressed in baculovirus infected Sf9 cells
• Saggio: 70-95% (SDS-PAGE)
• Stato: frozen liquid
• Attività specifica: 15-25 nmol/min·mg (radiometric)
• PM: ~69 kDa
• Concentrazione: 0.05-0.1 μg/μL
• Numero d’accesso: NM_001024401
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... SBK1(388228)

Descrizione

Applicazioni

Useful for kinase assay.

Azioni biochim/fisiol

Full-length recombinant human SBK1 was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. SBKI or SH3 domain binding kinase 1 is a novel serine/threonine protein kinase structurally related to a Xenopus gastrula-specific protein kinase, Pk9.7 which possessing a consensus sequence for an SH3-binding domain from developing rat brain and it play an important role in signal-transduction pathways related to the control of brain development ⁽¹⁾. SBK1 may predict a broad cellular function, and its dysregulated in certain cancers suggests an involvement of the protein in the pathogenesis of human cancers ⁽²⁾.

Ricostituzione

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Stoccaggio e stabilità

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

Note legali

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable