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Merck
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Key Documents

SRP0352

Sigma-Aldrich

TRKC active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Sinonimo/i:

NT-3 Receptor, NTKR3, Neurotrophic Tyrosine Kinase Receptor, type 3

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About This Item

Numero CAS:
2122170-03-8
Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in baculovirus infected Sf9 cells

Saggio

≥70% (SDS-PAGE)

Forma fisica

aqueous solution

PM

68 kDa

Confezionamento

pkg of 10 μg

tecniche

activity assay: suitable
inhibition assay: suitable

N° accesso NCBI

NM_002530

N° accesso UniProt

Q16288

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... NTRK3(4916)

Descrizione generale

Human TRKC, also known as NTKR3 (Neurotrophic Tyrosine Kinase Receptor, type 3) or NT-3 Receptor, (GenBank Accession No. NM_002530), amino acids 456-825 (end) with N-terminal GST-tag, MW=68kDa, expressed in Sf9 cells via a Baculovirus expression system.

Applicazioni

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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L Tessarollo et al.
Development (Cambridge, England), 118(2), 463-475 (1993-06-01)
The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily
L M McGregor et al.
Genomics, 22(2), 267-272 (1994-07-15)
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system. We have cloned and sequenced the human trkC cDNA and found that the predicted amino
F Lamballe et al.
Cell, 66(5), 967-979 (1991-09-06)
We report the isolation and molecular characterization of trkC, a new member of the trk family of tyrosine protein kinase genes. trkC is preferentially expressed in the brain. In situ hybridization studies revealed trkC transcripts in the hippocampus, cerebral cortex
Ke Zhang et al.
Stem cell reviews, 10(4), 612-625 (2014-05-03)
In the past decades, mesenchymal stem cells (MSCs) as a promising cell candidate have received the most attention in the treatment of spinal cord injury (SCI). However, due to the low survival rate and low neural differentiation rate, the grafted
Oswald Steward et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(42), 14013-14021 (2014-10-17)
We reported previously the formation of ectopic colonies in widespread areas of the nervous system after transplantation of fetal neural stem cells (NSCs) into spinal cord transection sites. Here, we characterize the incidence, distribution, and cellular composition of the colonies.
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