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Key Documents

SRP0310

HDAC6 H216A human

Name: HDAC6 H216A human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

Sinonimo/i:

HD6, JM21, histone deacetylase 6

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About This Item

Codice UNSPSC:

12352200

NACRES:

NA.32

Origine biologica

human

Ricombinante

expressed in baculovirus infected Sf9 cells

Saggio

≥75% (SDS-PAGE)

Forma fisica

aqueous solution

PM

161 kDa

Confezionamento

pkg of 50 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Concentrazione

0.65 mg/mL

N° accesso NCBI

NM_006044

N° accesso UniProt

Q9UBN7

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... HDAC6(10013)

Descrizione generale

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H216A results in catalytically inactive HDAC6.
Human HDAC6 with H216A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

Azioni biochim/fisiol

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Loss of a-Tubulin Acetylation Is Associated with TGF-?-induced Epithelial-Mesenchymal Transition.

Gu S, et al.

The Journal of Biological Chemistry, 291, 5396-5396 (2016)

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

Hook SS, et al.

Proceedings of the National Academy of Sciences of the USA, 99, 13425-13425 (2002)

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells.

Jiaqi Liu et al.

Journal of translational medicine, 14, 7-7 (2016-01-10)

Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mechanism

Li S. et al.

Neurology, 41, 112-116 (2010)

A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.

Simon D, et al.

Human Molecular Genetics, 19, 2015-2015 (2010)

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