SML1323

NU6140

≥98% (HPLC)

• Sinonimo/i: 4-[[6-(Cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide
• Formula empirica (notazione di Hill): C₂₃H₃₀N₆O₂
• Numero CAS: 444723-13-1
• Peso molecolare: 422.52
• Numero MDL: MFCD09264153
• Codice UNSPSC: 12352200
• ID PubChem: 329825785
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 20 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(N(CC)CC)C1=CC=C(NC2=NC(NC=N3)=C3C(OCC4CCCCC4)=N2)C=C1
• InChI: 1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28); XHEQSRJCJTWWAH-UHFFFAOYSA-N

Descrizione

Applicazioni

NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripotency of human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells.

Azioni biochim/fisiol

NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.

NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable