SMB00287

Formycin A

from Streptomyces kaniharaensis, ≥98% (HPLC)

• Sinonimo/i: 1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-(1S)-D-Ribitol, 7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidine, 8-Aza-9-deazaadenosine, Formycin, NSC 102811
• Formula empirica (notazione di Hill): C₁₀H₁₃N₅O₄
• Numero CAS: 6742-12-7
• Peso molecolare: 267.24
• Beilstein: 624229
• Numero MDL: MFCD00036807
• Codice UNSPSC: 51102829
• ID PubChem: 329824924
• NACRES: NA.85

Proprietà

• Origine biologica: Streptomyces kaniharaensis
• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: (Keep container tightly closed in a dry and well-ventilated place.)
• Colore: white to off-white
• Solubilità: DMSO: soluble 1 mg/mL; H₂O: soluble 3 mg/mL
• Spettro attività antibiotica: viruses (Antiretroviral)
• Modalità d’azione: enzyme | inhibits
• Temperatura di conservazione: −20°C
• Stringa SMILE: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1; OIRDTQYFTABQOQ-KQYNXXCUSA-N
• Informazioni sul gene: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

Descrizione

Descrizione generale

Chemical structure: nucleoside

Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.

Azioni biochim/fisiol

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.

Formycin A possess antitumor function, along with its antibacterial and antiviral activity.

Confezionamento

10MG

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable