SCP0063

Calpastatin Peptide

≥95% (HPLC), Ac 184-210

• Formula empirica (notazione di Hill): C₁₄₂H₂₃₀N₃₆O₄₄S₁
• Peso molecolare: 3177.63
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Nome del prodotto: Calpastatin Peptide Ac 184-210, ≥95% (HPLC)
• Saggio: ≥95% (HPLC)
• Stato: lyophilized
• Composizione: Peptide Content, ≥75%
• Condizioni di stoccaggio: protect from light
• Temperatura di conservazione: −20°C

Descrizione

Amino Acid Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Applicazioni

Calpastatin Peptide Ac 184-210 has been used as the endogenous calpain inhibitor to study its effects on myristoylated alanine-rich C kinase substrate (MARCKS) cleavage in mouse kidney cells. It has also been used as a calpain inhibitor to examine its effects on the formation of DNA-platinum adducts by cisplatin (CDDP) in neuronal cells.

Azioni biochim/fisiol

Calpastatin, a component of the calpain/calpastatin system, is a calpain (calcium-dependent cysteine protease) inhibitor. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation.

Calpastatin, located in the cytosol, is involved in selective protein cleavage in response to calcium signaling.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable