SAB5500169

Anti-PTEN antibody, Rabbit monoclonal

clone SP218, recombinant, expressed in proprietary host, affinity isolated antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Ricombinante: expressed in proprietary host
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: SP218, monoclonal
• Reattività contro le specie: human (tested)
• Reattività contro le specie (prevista in base all’omologia): mouse, dog, frog
• tecniche: flow cytometry: 1:200; immunoblotting: 1:400; immunohistochemistry: 1:200
• Isotipo: IgG
• N° accesso UniProt: P60484
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PTEN(5728)

Descrizione

Descrizione generale

Phosphatase and tensin homolog deleted on chromosome ten (PTEN), a lipid phosphatase protein, is localized in the cell nucleus. It has a protein tyrosine phosphatase domain. The PTEN gene is located on human chromosome 10q23.

Immunogeno

Synthetic peptide derived from the C-terminus of human PTEN protein.

Azioni biochim/fisiol

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a tumor suppressor gene. It negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway. PTEN protein might control the growth of cells through its lipid phosphatase activity. The protein tyrosine phosphatase domain of PTEN is known to dephosphorylate serine, threonine, and tyrosine residues. It may also participate in immune modulation. Mutation in the PTEN gene is associated with rare bilateral choroidal ganglioneuroma. Germline mutations in the PTEN gene are observed in Cowden′s syndrome (CS), Lhermitte–Duclos disease (LDD), and Bannayan–Zonana syndrome (BZS).

Caratteristiche e vantaggi

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Stato fisico

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable