SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

• Sinonimo/i: HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E
• Codice UNSPSC: 12352203

Proprietà

• Coniugato: unconjugated
• Livello qualitativo: 100
• Tipo di anticorpo: primary antibodies
• Clone: MEM-E/02, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: ( Non-human primates), human
• Concentrazione: 1 mg/ml
• tecniche: immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG1
• N° accesso UniProt: P13747
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HLA-E(3133)

Descrizione

Descrizione generale

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

Specificità

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

Immunogeno

Recombinant human HLA-E denaturated heavy chain.

Stato fisico

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota sulla preparazione

Purified by protein-A affinity chromatography.

Stoccaggio e stabilità

Store at 2-8°C. Do not freeze.

Altre note

The antibody solution should be gently mixed before use.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable