SAB4504721
Anti-phospho-p47 phox (pSer345) antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
antigen 44 kDa
Reattività contro le specie
rat, human, mouse
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
phosphorylation (pSer345)
Informazioni sul gene
human ... NCF1(653361)
Descrizione generale
The neutrophil cytosolic factor 1 (NCF1), also known as p47phox gene, spanning 15kb with 11 exons, is mapped to human chromosome 7q11.23. The gene codes for a 390 amino acid protein, which is a novel component of the NADPH oxidase complex.
Immunogeno
The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser345.
Immunogen Range: 311-360
Immunogen Range: 311-360
Azioni biochim/fisiol
Neutrophil cytosolic factor 1 (NCF1) stimulates the production of reactive oxygen species (ROS) under hyperoxic condition. The above process can be inhibited by the NCF1 inhibitor diphenylene iodonium (DPI) and apocynin. Mutation in the gene leads to a rare congenital immune deficiency called, chronic granulomatous disease (CGD). Deletion of NCF1 gene, which is a vital component of NADPH oxidase complex implicated in generation of oxidative stress, leads to Williams syndrome. It also act as a modifier of vascular stiffness.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Astghik Hayrapetyan et al.
Biochimica et biophysica acta, 1832(10), 1662-1672 (2013-05-22)
Chronic granulomatous disease (CGD) is a rare congenital disorder in which phagocytes cannot generate superoxide (O2(-)) and other microbicidal oxidants due to mutations in one of the five components of the O2(-)-generating NADPH oxidase complex. The most common autosomal subtype
Beth A Kozel et al.
Hypertension (Dallas, Tex. : 1979), 63(1), 74-79 (2013-10-16)
Williams syndrome is caused by the deletion of 26 to 28 genes, including elastin, on human chromosome 7. Elastin insufficiency leads to the cardiovascular hallmarks of this condition, namely focal stenosis and hypertension. Extrapolation from the Eln(+/-) mouse suggests that
Martin de Boer et al.
Blood cells, molecules & diseases, 55(4), 320-327 (2015-10-16)
Chronic granulomatous disease (CGD) is a rare congenital immune deficiency caused by mutations in any of the five genes encoding NADPH oxidase subunits. One of these genes is NCF1, encoding the p47(phox) protein. A group of 39 patients, 14 of
Lingping Zhang et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(1), 59-62 (2016-01-06)
To observe the effects of NADPH oxidase inhibitor diphenylene iodonium (DPI) and apocynin on the generation of reactive oxygen species (ROS) induced by p47phox and the mechanism of p47phox-induced ROS production under hyperoxic conditions. Peripheral blood mononuclear cells (PBMCs) were
U Francke et al.
American journal of human genetics, 47(3), 483-492 (1990-09-01)
Chronic granulomatous disease (CGD) is a heterogeneous group of inherited disorders of impaired superoxide production in phagocytes. The most common X-linked recessive form involves the CYBB locus in band Xp21.1 that encodes the membrane-bound beta subunit of the cytochrome b558
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