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SAB4503501

Sigma-Aldrich

Anti-Cyclin B1 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

CCN-2, CCNB, CCNB1, CCNB1-RS1, CYCB

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 48 kDa

Reattività contro le specie

rat, human, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CCNB1(891)

Descrizione generale

Anti-Cyclin B1 Antibody detects endogenous levels of total Cyclin B1 protein.
Cyclin B1 belongs to the cyclin family. It is a 48.337kDa protein. It is present in low level in testis, thymus, bone marrow and smooth muscle. It is mapped to human chromosome 5q13.2.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Cyclin B1.

Immunogen Range: 91-140

Applicazioni

Anti-Cyclin B1 antibody has been used in western-blot analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Azioni biochim/fisiol

Cyclin B1-CDK1 (cyclin-dependent kinase 1) helps to induce chromosome condensation, nuclear lamina resolution and mitotic spindle assembly. It also acts as a potential target for a cancer vaccine.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Visita l’Archivio dei documenti

CCNB1 (cyclin B1)
Perez-Stable C
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain
Chen Y, et al.
Oncotarget, 8(1), 1234-1246 (2017)
The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors
Chevaleyre C, et al.
Journal of Immunology, 195(4), 1891-1901 (2015)
PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression
Qu X, et al.
Journal of Translational Medicine, 13(1), 301-301 (2015)
Yunyu Chen et al.
Oncotarget, 8(1), 1234-1246 (2016-12-03)
Polo-like kinase 1 (Plk1) is a promising target for cancer therapy due to its essential role in cell division. In addition to a highly conserved kinase domain, Plk1 also contains a Polo-Box domain (PBD), which is essential for Plk1's subcellular

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